Nature Machine Intelligence, Published online: 02 July 2026; doi:10.1038/s42256-026-01264-2

Liu and colleagues introduce HelixFold-S1, a guided sampling strategy for biomolecular complex structure prediction that targets high-probability interaction regions. The method achieves higher accuracy than traditional unguided methods while reducing computational costs.

Nature Machine Intelligence, Published online: 04 June 2026; doi:10.1038/s42256-026-01249-1

Yang et al. developed CrossDNA, a parameter-efficient language model for cross-strand DNA modelling inspired by double-strand dynamics. It performs strongly in benchmarks and supports regulatory region interpretation and non-coding variant prioritization.