Nature Machine Intelligence, Published online: 11 June 2026; doi:10.1038/s42256-026-01244-6

Synthetic datasets are becoming crucial for the development of biomedical machine learning models. Victoriano et al. discuss the persistent simulation-to-reality gap that limits how well synthetic performance predicts real-world performance.

Nature Machine Intelligence, Published online: 11 June 2026; doi:10.1038/s42256-026-01250-8

Xiong et al. introduce ConfSeq, a molecular conformation description language that enables language models to perform three-dimensional molecular modelling tasks, including conformer prediction, three-dimensional molecular generation and representation, with strong performance.